Abstract |
Elevated serum phosphorus and calcium are associated with arterial calcification and mortality in dialysis patients. Unlike calcium-based binders, sevelamer attenuates arterial calcification but it is unknown whether sevelamer affects mortality or morbidity. In a multicenter, randomized, open-label, parallel design trial we compared sevelamer and calcium-based binders on all-cause and cause-specific mortality ( cardiovascular, infection, and other) in prevalent hemodialysis patients. A total of 2103 patients were initially randomized to treatment and 1068 patients completed the study. All-cause mortality rates and cause-specific mortality rates were not significantly different. There was a significant age interaction on the treatment effect. Only in patients over 65 years of age was there a significant effect of sevelamer in lowering the mortality rate. There was a suggestion that sevelamer was associated with lower overall, but not cardiovascular-linked, mortality in older patients. We suggest that further research is needed to confirm these findings.
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Authors | W N Suki, R Zabaneh, J L Cangiano, J Reed, D Fischer, L Garrett, B N Ling, S Chasan-Taber, M A Dillon, A T Blair, S K Burke |
Journal | Kidney international
(Kidney Int)
Vol. 72
Issue 9
Pg. 1130-7
(Nov 2007)
ISSN: 0085-2538 [Print] United States |
PMID | 17728707
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acetates
- Calcium Compounds
- Chelating Agents
- Polyamines
- Phosphorus
- Sevelamer
- Calcium Carbonate
- Calcium
- calcium acetate
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Topics |
- Acetates
(adverse effects, therapeutic use)
- Adult
- Age Factors
- Aged
- Calcium
(blood)
- Calcium Carbonate
(adverse effects, therapeutic use)
- Calcium Compounds
(adverse effects, therapeutic use)
- Cardiovascular Diseases
(etiology, mortality, prevention & control)
- Chelating Agents
(adverse effects, therapeutic use)
- Chronic Disease
- Female
- Humans
- Kidney Diseases
(complications, therapy)
- Male
- Middle Aged
- Phosphorus
(blood)
- Polyamines
(adverse effects, therapeutic use)
- Renal Dialysis
(mortality)
- Sevelamer
- Treatment Outcome
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