Abstract | BACKGROUND: METHODS: A meta-analysis of randomized controlled trials (RCT) was performed comparing RT treatment for DCIS of breast cancer to observation. The MEDLINE, EMBASE, CANCERLIT, Cochrane Library databases, Trial registers, bibliographic databases, and recent issues of relevant journals were searched. Relevant reports were reviewed by two reviewers independently and the references from these reports were searched for additional trials, using guidelines set by QUOROM statement criteria. RESULTS: The reviewers identified four large RCTs, yielding 3665 patients. Pooled results from this four randomized trials of adjuvant radiotherapy showed a significant reduction of invasive and DCIS ipsilateral breast cancer with odds ratio (OR) of 0.40 (95% CI 0.33-0.60, p < 0.00001) and 0.40 (95% CI 0.31-0.53, p < 0.00001), respectively. There was not difference in distant metastases (OR = 1.04, 95% CI 0.57-1.91, p = 0.38) and death rates (OR = 1.08, 95%CI 0.65-1.78, p = 0.45) between the two arms. There was more contralateral breast cancer after adjuvant RT (66/1711 = 3.85%) versus observation (49/1954 = 2.5%). The likelihood of contralateral breast cancer was 1.53-fold higher (95% CI 1.05-2.24, p = 0.03) in radiotherapy arms. CONCLUSION: The conclusion from our meta-analysis is that the addition of radiation therapy to lumpectomy results in an approximately 60% reduction in breast cancer recurrence, no benefit for survival or distant metastases compared to excision alone. Patients with high-grade DCIS lesions and positive margins benefited most from the addition of radiation therapy. It is not yet clear which patients can be successfully treated with lumpectomy alone; until further prospective studies answer this question, radiation should be recommended after lumpectomy for all patients without contraindications.
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Authors | Gustavo A Viani, Eduardo J Stefano, Sérgio L Afonso, Lígia I De Fendi, Francisco V Soares, Paola G Leon, Flavio S Guimarães |
Journal | Radiation oncology (London, England)
(Radiat Oncol)
Vol. 2
Pg. 28
(Aug 02 2007)
ISSN: 1748-717X [Electronic] England |
PMID | 17683529
(Publication Type: Journal Article, Meta-Analysis)
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Topics |
- Breast
(surgery)
- Breast Neoplasms
(radiotherapy, surgery)
- Carcinoma, Intraductal, Noninfiltrating
(radiotherapy, surgery)
- Disease-Free Survival
- Female
- Humans
- Mastectomy, Segmental
(methods)
- Neoplasm Metastasis
- Radiotherapy, Adjuvant
(methods)
- Randomized Controlled Trials as Topic
- Recurrence
- Reproducibility of Results
- Treatment Outcome
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