Evaluation of four whole-cell Leptospira-based serological tests for diagnosis of urban leptospirosis.

Abstract

Four serologic assays for leptospirosis had sensitivities of 72 to 88% and specificities of 88 to 100% in the setting of highly endemic urban transmission, indicating that assays using enzyme-linked immunosorbency and rapid formats may be used as alternatives to the microscopic agglutination test for diagnosing urban leptospirosis. Testing a second sample will be required in cases with an initial negative result, since sensitivity was low (46 to 68%) during the first week of illness.

• Authors: Alan J A McBride, Balbino L Santos, Adriano Queiroz, Andréia C Santos, Rudy A Hartskeerl, Mitermayer G Reis, Albert I Ko
• Journal: Clinical and vaccine immunology : CVI (Clin Vaccine Immunol) Vol. 14 Issue 9 Pg. 1245-8 (Sep 2007) ISSN: 1556-6811 [Print] United States
• PMID: 17652521 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Topics

• Enzyme-Linked Immunosorbent Assay (methods)
• Humans
• Leptospira (immunology)
• Leptospirosis (diagnosis, immunology, transmission)
• Sensitivity and Specificity
• Serologic Tests (methods, standards)