Efficacy of beclomethasone dipropionate HFA 200 microg once daily in chronic obstructive pulmonary disease and bronchial asthma.

Abstract

The efficacy and safety of once-daily beclomethasone dipropionate (BDP; 200 microg), in combination with the propellant hydrofluoroalkane-134a (HFA) was compared with that of budesonide turbuhaler (BUD-TH) 400 microg twice daily and fluticasone propionate inhaler (FP-IH) 250 microg twice daily in 40 patients with bronchial asthma or chronic obstructive pulmonary disease. All patients had used inhaled corticosteroids for at least 1 month. On randomization, 20 patients were switched to HFA-BDP and 20 patients remained on their existing BUD-TH or FP-IH treatment. After 8 weeks, HFA-BDP demonstrated a greater improvement in spirometric values, respiratory symptoms and beta2-agonist use. No significant local adverse effects were observed. Blood cortisol levels remained in the normal range in both groups. We conclude that HFA-BDP (200 microg once-daily) offered more benefit in terms of clinical and spirometry indices than BUD-TH (400 microg twice daily) or FP-IH (250 microg twice daily) in patients with moderate asthma and chronic obstructive pulmonary disease.

• Authors: G Tatsis, K Kotsifas, V Filaditaki, G Makrantoni, S Boulia
• Journal: The Journal of international medical research (J Int Med Res) 2007 May-Jun Vol. 35 Issue 3 Pg. 361-73 ISSN: 0300-0605 [Print] England
• PMID: 17593865 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Adrenergic beta-Agonists
• Aerosol Propellants
• Androstadienes
• Anti-Asthmatic Agents
• Hydrocarbons, Fluorinated
• Budesonide
• Fluticasone
• Beclomethasone
• Albuterol
• apaflurane
• Hydrocortisone

Topics

• Adrenergic beta-Agonists (therapeutic use)
• Adult
• Aerosol Propellants (administration & dosage, adverse effects, therapeutic use)
• Albuterol (therapeutic use)
• Androstadienes (administration & dosage, therapeutic use)
• Anti-Asthmatic Agents (administration & dosage, adverse effects, therapeutic use)
• Asthma (drug therapy)
• Beclomethasone (administration & dosage, adverse effects, therapeutic use)
• Budesonide (administration & dosage, therapeutic use)
• Female
• Fluticasone
• Humans
• Hydrocarbons, Fluorinated (administration & dosage, adverse effects, therapeutic use)
• Hydrocortisone (blood)
• Male
• Middle Aged
• Nebulizers and Vaporizers
• Patient Compliance
• Pulmonary Disease, Chronic Obstructive (drug therapy)
• Spirometry