[The significance of protein C deficiency in dermatology].

Abstract

The protein C system is a physiological inhibitor of coagulation and is important for the regulation of hemostasis. Protein C deficiencies can be inherited or acquired, and they lead to enhanced thrombophilia. A number of clinical entities that are also of interest to dermatologists have been related to protein C deficiency. Inherited protein C deficiency can become manifest in various ways, e.g. as purpura fulminans neonatalis, as recurrent episodes of thrombosis and as coumarin necrosis. Acquired protein C deficiency can be observed in the course of purpura fulminans, disseminated intravascular coagulation, hepatic failure or in the presence of antiphospholipid antibodies. The clinical features, the possible pathogenesis and the therapy of these manifestations are briefly discussed.

• Authors: R Feldmann, M Harms
• Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (Hautarzt) Vol. 42 Issue 10 Pg. 607-12 (Oct 1991) ISSN: 0017-8470 [Print] Germany
• Vernacular Title: Die Bedeutung des Protein-C-Mangels in der Dermatologie.
• PMID: 1757253 (Publication Type: English Abstract, Journal Article, Review)

Topics

• Humans
• Protein C Deficiency
• Purpura (blood, genetics)
• Thromboembolism (blood, genetics)