Abstract |
Sea-blue histiocytosis is a rare disorder seen in patients with lipid metabolic or ceroid storage diseases. Sea-blue histiocytes are ceroid-laden macrophages detectable by May-Giemsa staining. We report a case of a 28-year-old woman diagnosed with Niemann-Pick disease at 2 or 3 years of age. To confirm this diagnosis, we examined her bone marrow, which revealed scattered foci containing aggregates of foamy macrophages. May-Giemsa staining identified blue-staining foamy macrophages, referred to as sea-blue histiocytes. In summary, we report the detection of sea-blue histiocytosis in an adult with Niemann-Pick disease.
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Authors | Osamu Suzuki, Masafumi Abe |
Journal | Journal of clinical and experimental hematopathology : JCEH
(J Clin Exp Hematop)
Vol. 47
Issue 1
Pg. 19-21
(Apr 2007)
ISSN: 1346-4280 [Print] Japan |
PMID | 17510534
(Publication Type: Case Reports, Journal Article)
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Topics |
- Adult
- Bone Marrow Cells
(pathology)
- Bone Marrow Examination
- Female
- Humans
- Immunohistochemistry
- Leukocytes
(enzymology)
- Macrophages
(pathology)
- Niemann-Pick Diseases
(complications, diagnosis)
- Sea-Blue Histiocyte Syndrome
(diagnosis, etiology)
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