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Secondary sea-blue histiocytosis derived from Niemann-Pick disease.

Abstract
Sea-blue histiocytosis is a rare disorder seen in patients with lipid metabolic or ceroid storage diseases. Sea-blue histiocytes are ceroid-laden macrophages detectable by May-Giemsa staining. We report a case of a 28-year-old woman diagnosed with Niemann-Pick disease at 2 or 3 years of age. To confirm this diagnosis, we examined her bone marrow, which revealed scattered foci containing aggregates of foamy macrophages. May-Giemsa staining identified blue-staining foamy macrophages, referred to as sea-blue histiocytes. In summary, we report the detection of sea-blue histiocytosis in an adult with Niemann-Pick disease.
AuthorsOsamu Suzuki, Masafumi Abe
JournalJournal of clinical and experimental hematopathology : JCEH (J Clin Exp Hematop) Vol. 47 Issue 1 Pg. 19-21 (Apr 2007) ISSN: 1346-4280 [Print] Japan
PMID17510534 (Publication Type: Case Reports, Journal Article)
Topics
  • Adult
  • Bone Marrow Cells (pathology)
  • Bone Marrow Examination
  • Female
  • Humans
  • Immunohistochemistry
  • Leukocytes (enzymology)
  • Macrophages (pathology)
  • Niemann-Pick Diseases (complications, diagnosis)
  • Sea-Blue Histiocyte Syndrome (diagnosis, etiology)

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