Graft versus leukemia effect against juvenile myelomonocytic leukemia after unrelated cord blood transplantation.

Abstract

A 13-month-old female underwent unrelated cord blood transplantation (CBT) for juvenile myelomonocytic leukemia (JMML). In spite of progression of the disease after a conditioning regimen with high-dose chemotherapy, a complete remission was induced in concordance with development of acute GVHD after reduction of the immunosupressant. She has been in complete remission for 1 year after transplantation. This case illustrates that CBT can provide a potent graft versus leukemia (GVL) effect against JMML.

• Authors: Reo Tanoshima, Hiroaki Goto, Masakatsu Yanagimachi, Ryosuke Kajiwara, Fumiko Kuroki, Shumpei Yokota
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 50 Issue 3 Pg. 665-7 (Mar 2008) ISSN: 1545-5017 [Electronic] United States
• PMID: 17437289 (Publication Type: Case Reports, Journal Article)
• Copyright: (c) 2007 Wiley-Liss, Inc.

Chemical References

• Immunosuppressive Agents
• Cyclosporine

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Combined Modality Therapy
• Cord Blood Stem Cell Transplantation
• Cyclosporine (therapeutic use)
• Diseases in Twins
• Female
• Graft vs Host Disease (etiology)
• Graft vs Leukemia Effect
• Humans
• Immunosuppressive Agents (therapeutic use)
• Infant
• Leukemia, Myelomonocytic, Juvenile (drug therapy, surgery)
• Male
• Remission Induction