Abstract | BACKGROUND: The objective of this study was to elucidate the relation between respiratory syncytial virus ( RSV) infection and cytokine/ chemokine concentrations, as well as the impact that these factors have on the severity of bronchiolitis. METHODS: Children <24 months old who presented to the emergency department with clinical symptoms of bronchiolitis were prospectively enrolled in the study. Nasal-wash samples were analyzed to identify viral pathogens and to quantify RSV and cytokine/ chemokine concentrations. Severe cases of disease were defined as those requiring hospitalization, and severity was further determined on the basis of the duration of supplemental- oxygen and/or intravenous- fluid therapy. RESULTS: CONCLUSION:
|
Authors | Berkeley L Bennett, Roberto P Garofalo, Stanley G Cron, Yashoda M Hosakote, Robert L Atmar, Charles G Macias, Pedro A Piedra |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 195
Issue 10
Pg. 1532-40
(May 15 2007)
ISSN: 0022-1899 [Print] United States |
PMID | 17436234
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Bronchiolitis
(immunology, pathology, virology)
- Chemokines
(analysis)
- Cytokines
(analysis)
- Female
- Genetic Predisposition to Disease
- Heart Defects, Congenital
(complications)
- Humans
- Infant
- Infant, Newborn
- Infant, Premature
- Male
- Nasal Mucosa
(physiopathology)
- Prospective Studies
- Respiratory Syncytial Virus Infections
(immunology, pathology)
- Respiratory Syncytial Viruses
(genetics, immunology, isolation & purification)
- Respiratory Tract Infections
(virology)
|