Onset of efficacy of tolterodine extended release in patients with overactive bladder.

Abstract

OBJECTIVE:

To assess the onset of efficacy of tolterodine extended release (ER) in patients with overactive bladder (OAB).

RESEARCH DESIGN AND METHODS:

A post hoc analysis was conducted using 3-day bladder diary data from a 12-week, multicenter, prospective, open-label study of tolterodine ER (4 mg qd) in patients (aged > or = 18 years) with urinary frequency (> or = 8 micturitions/24 h) and urgency (strong and sudden desire to urinate) with or without urgency urinary incontinence (UUI).

MAIN OUTCOME MEASURES:

Changes in micturition frequency, urgency, and UUI episodes/24 h were evaluated for treatment Days 5, 6, and 7. The percentages of patients who achieved normal micturition frequency (< 8/day) and 50%, 70%, 90%, and 100% reductions in urgency and UUI episodes (i.e., responders) were determined at Days 5, 6, and 7. Week 12 data are presented as a referent for the magnitude of treatment efficacy during Week 1.

RESULTS:

This analysis included 698 patients. On Day 5, there were significant reductions in all three diary variables (all p < 0.0001), and improvements continued on Days 6 and 7. More than half of the patients reported > or = 50% reductions in urgency or UUI episodes on Day 5. Responder rates for all three symptoms increased through Week 12.

CONCLUSIONS:

Patients with OAB experienced significant reductions in OAB symptoms as early as Day 5 of treatment with tolterodine ER. These data extend the findings of a previous analysis, in which all 3 days of the bladder diary were pooled, that demonstrated improvements in micturition frequency, urgency episodes, and UUI episodes in patients with OAB after 1 week of treatment with tolterodine ER. Limitations are that efficacy was not assessed before Day 5, this was a post hoc analysis, and the study was not placebo-controlled.

• Authors: David O Sussman, Stephen R Kraus, Martin Carlsson, Zhonghong Guan
• Journal: Current medical research and opinion (Curr Med Res Opin) Vol. 23 Issue 4 Pg. 777-81 (Apr 2007) ISSN: 1473-4877 [Electronic] England
• PMID: 17407634 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Benzhydryl Compounds
• Cresols
• Delayed-Action Preparations
• Muscarinic Antagonists
• Phenylpropanolamine
• Tolterodine Tartrate

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Benzhydryl Compounds (administration & dosage, therapeutic use)
• Cresols (administration & dosage, therapeutic use)
• Delayed-Action Preparations (administration & dosage, therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Muscarinic Antagonists (administration & dosage)
• Phenylpropanolamine (administration & dosage, therapeutic use)
• Time Factors
• Tolterodine Tartrate
• Treatment Outcome
• Urinary Bladder, Overactive (drug therapy)