[Mastocytosis--mastcell proliferative disease risk of anaphylactic reaction].

Abstract

Mastocytosis is a group of rare diseases characterized by abnormal growth of mast cells in skin, bone marrow, liver, spleen, lymph nodes. Signs and symptoms result mostly from mast cells mediators and mast cells organ infiltration. Pathological examination proving mast cells infiltration is crucial for the diagnosis of disease. Therapy covers patient education and symptomatic treatment (antihistamine drugs and glicocortycoids). Attempts of interferon, cladribine, imatinib treatment are made. Aggressive forms of diseases require, chemiotherapy, bone marrow transplantation. All mastocytosis subjects should be equipped in adrenaline. The paper describes case of 52 years old woman who suffered from urticaria pigmenthosa, anaphylaxis, insect venom and food allergy. Diagnosis included bone marrow examinations (pathology, cytology, genetics, cytofotometry) tryptase level, skin prick tests and sIgE. Mastocytosis was diagnosed. Therapy included symptomatic treatment and immunotherapy. The paper describes also aims of the European Competence Network on Mastocytosis.

• Authors: Marek Niedoszytko
• Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego (Pol Merkur Lekarski) Vol. 21 Issue 126 Pg. 570-2 (Dec 2006) ISSN: 1426-9686 [Print] Poland
• Vernacular Title: Mastocytoza--rozrostowa choroba komórek tucznych zwiazana z ryzykiem reakcji anafilaktycznej.
• PMID: 17405300 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Arthropod Venoms
• Tryptases

Topics

• Anaphylaxis (immunology, therapy)
• Arthropod Venoms (immunology)
• Bone Marrow Examination (methods)
• Female
• Food Hypersensitivity (immunology)
• Humans
• Hypersensitivity (immunology)
• Mast Cells (immunology, metabolism)
• Mastocytoma (immunology)
• Mastocytosis (immunology, pathology, therapy)
• Middle Aged
• Rare Diseases
• Skin (immunology, pathology)
• Treatment Outcome
• Tryptases (metabolism)
• Urticaria Pigmentosa (immunology, therapy)