[Osteoclast differentiation and activation].

Abstract

In autoimmune arthritis, activation of T cells induces bone destruction through receptor activator of NF-kappaB ligand (RANKL) . Recent study revealed interleukin-17 (IL-17) -producing helper T cell subset (Th17) , but not IFN-gamma-producing Th1, to be responsible for bone destruction. Here we summarize the current understanding of osteoclast differentiation and activation in the context of osteoimmunology.

• Authors: Hiroshi Takayanagi
• Journal: Clinical calcium (Clin Calcium) Vol. 17 Issue 4 Pg. 484-92 (Apr 2007) ISSN: 0917-5857 [Print] Japan
• PMID: 17404476 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Interleukin-17
• RANK Ligand

Topics

• Animals
• Arthritis, Rheumatoid (immunology, pathology)
• Bone and Bones (immunology, pathology)
• Cell Differentiation
• Humans
• Interleukin-17 (biosynthesis)
• Lymphocyte Activation
• Osteoclasts (cytology)
• RANK Ligand (physiology)
• Signal Transduction (physiology)
• T-Lymphocyte Subsets (immunology)
• T-Lymphocytes, Helper-Inducer (immunology)