Abstract | BACKGROUND AND OBJECTIVES: MATERIAL AND METHODS: RESULTS: Both Th1 (interleukin-12p40, IFN-gamma, TNF) and Th2 (interleukin-10, interleukin-4) knockout mice exhibited significantly more alveolar bone loss than their respective wild-type control mice (p<0.001). Interleukin-10-/- and interleukin-12p40-/- mice exhibited a three-fold increase in alveolar bone loss at 30 wk of age, whereas bone loss in IFN-gamma-/-, TNF-/- and interleukin-4-/- mice was 1.5- to two-fold higher compared with wild-type control mice. CONCLUSION: The results of the present study indicate that both Th1 and Th2 cytokines play an important role in maintaining alveolar bone homeostasis. The kinetics of alveolar bone loss seen in cytokine gene knockout mice indicates that bone loss is age dependent and late in onset.
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Authors | J Alayan, S Ivanovski, C S Farah |
Journal | Journal of periodontal research
(J Periodontal Res)
Vol. 42
Issue 2
Pg. 97-103
(Apr 2007)
ISSN: 0022-3484 [Print] United States |
PMID | 17305866
(Publication Type: Journal Article)
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Chemical References |
- Cytokines
- Interleukins
- Tumor Necrosis Factor-alpha
- Interferon-gamma
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Topics |
- Age Factors
- Alveolar Bone Loss
(genetics)
- Analysis of Variance
- Animals
- Cytokines
(genetics, physiology)
- Female
- Gene Deletion
- Gene Targeting
- Interferon-gamma
(genetics, physiology)
- Interleukins
(genetics, physiology)
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Specific Pathogen-Free Organisms
- Th1 Cells
(physiology)
- Th2 Cells
(physiology)
- Tumor Necrosis Factor-alpha
(genetics, physiology)
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