Factors associated with dopaminergic drug-related pathological gambling in Parkinson disease.

Abstract

OBJECTIVE:

To evaluate factors associated with pathological gambling (PG) in Parkinson disease (PD).

DESIGN:

Case-control study.

SETTING:

Outpatient tertiary clinic. Patients Twenty-one patients with idiopathic PD with PG after the patients began receiving medications compared with a consecutive sample of 42 patients with idiopathic PD without compulsive behaviors.

MAIN OUTCOME MEASURES:

Clinical features, comorbid psychiatric and substance use disorders, personality traits, and impulsivity scores.

RESULTS:

Patients with PG had a younger age at PD onset (P = .006), higher novelty seeking (P<.001), medication-induced hypomania or mania (P = .001), impaired planning (P = .002), or a personal or immediate family history of alcohol use disorders (P = .002). Novelty seeking, a personal or immediate family history of alcohol use disorders, and younger age at PD onset accurately predicted PG at 83.7% in a logistic regression model, with the model accounting for 62% of the variance.

CONCLUSIONS:

Patients with PD having a younger age at PD onset, higher novelty seeking traits, and a personal or family history of alcohol use disorders may have a greater risk for PG with dopamine agonists.

• Authors: Valerie Voon, Teri Thomsen, Janis M Miyasaki, Minella de Souza, Ariel Shafro, Susan H Fox, Sarah Duff-Canning, Anthony E Lang, Mateusz Zurowski
• Journal: Archives of neurology (Arch Neurol) Vol. 64 Issue 2 Pg. 212-6 (Feb 2007) ISSN: 0003-9942 [Print] United States
• PMID: 17296836 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Dopamine Agents

Topics

• Aged
• Case-Control Studies
• Dopamine Agents (adverse effects)
• Exploratory Behavior
• Female
• Gambling
• Humans
• Logistic Models
• Male
• Middle Aged
• Parkinson Disease (epidemiology, psychology)
• Personality Inventory
• Psychiatric Status Rating Scales
• Statistics, Nonparametric