Abstract | BACKGROUND: METHODS: In a double-masked placebo-controlled clinical trial, 31 eyes of 31 patients were randomly assigned to two groups. Patients with history of trauma < or =7 days were included. Unconscious patients, eyes with penetrating trauma and candidates for decompression surgery were excluded. The treatment group (16 eyes) received 250 mg methylprednisolone intravenously every 6 h for 3 days, then 1 mg/kg prednisolone orally for 14 days; the placebo group (15 eyes) received 50 ml normal saline intravenously every 6 h for 3 days, then placebo for 14 days. Visual improvement was considered as a decrease of at least 0.4 logMAR in final visual acuity. RESULTS: Mean final BCVA (best corrected visual acuity) in the treatment group was 1.11+/- 1.14 and the placebo group was 1.78 +/- 1.23. This difference was not significant (P = 0.13). Visual acuity was improved in 68.8% of the treatment group and 53.3% of the placebo group, but the difference was not statistically significant (P = 0.38). The difference between initial and final BCVA in both groups was determined to be statistically significant (P < 0.001 and 0.010 respectively). CONCLUSIONS: Our study confirms earlier findings that there is no difference in visual acuity improvement between intravenous high-dose corticosteroids and placebo in treatment of recent TNO.
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Authors | Morteza Entezari, Zhaleh Rajavi, Neda Sedighi, Narssis Daftarian, Masoumeh Sanagoo |
Journal | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
(Graefes Arch Clin Exp Ophthalmol)
Vol. 245
Issue 9
Pg. 1267-71
(Sep 2007)
ISSN: 0721-832X [Print] Germany |
PMID | 17265030
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Glucocorticoids
- Prednisolone
- Methylprednisolone
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Topics |
- Administration, Oral
- Adolescent
- Adult
- Child
- Double-Blind Method
- Glucocorticoids
(administration & dosage)
- Humans
- Infusions, Intravenous
- Male
- Methylprednisolone
(administration & dosage)
- Middle Aged
- Optic Nerve Injuries
(drug therapy, physiopathology)
- Prednisolone
(administration & dosage)
- Prognosis
- Visual Acuity
- Wounds, Nonpenetrating
(drug therapy, physiopathology)
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