[Comparison of two schemes of administering the Russian protamine sulfate after extracorporeal circulation in cardiosurgical patients].

Abstract

The paper presents data of a study comparing two schemes (Scheme 1: a heparin/protamine ratio of 1:2; Scheme 2: a heparin/protamine ratio of 1:3) for administering protamine sulfate to neutralize heparin in patients after extracorporeal circulation. A larger dose of protamine sulfate is shown to induce significant thrombocytic dysfunction, resulting in increased postoperative hemorrhage. To minimize protamine sulfate doses required for neutralization of the anticoagulant effect of heparin is a way of preventing these complications.

• Authors: M A Charnaia, Iu A Morozov, V G Gladysheva, A M Isaeva
• Journal: Anesteziologiia i reanimatologiia (Anesteziol Reanimatol) 2006 Sep-Oct Issue 5 Pg. 31-3 ISSN: 0201-7563 [Print] Russia (Federation)
• PMID: 17184058 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Heparin Antagonists
• Protamines

Topics

• Blood Platelets (drug effects)
• Coronary Artery Bypass
• Extracorporeal Circulation
• Hemostasis (drug effects)
• Heparin Antagonists (administration & dosage, adverse effects)
• Humans
• Postoperative Care
• Protamines (administration & dosage, adverse effects)