Abstract |
We previously demonstrated that Borrelia burgdorferi requires OspC to colonize a mammalian host. To delineate this requirement, we analyzed the clearance of ospC mutant spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission.
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Authors | Kit Tilly, Aaron Bestor, Mollie W Jewett, Patricia Rosa |
Journal | Infection and immunity
(Infect Immun)
Vol. 75
Issue 3
Pg. 1517-9
(Mar 2007)
ISSN: 0019-9567 [Print] United States |
PMID | 17158906
(Publication Type: Journal Article, Research Support, N.I.H., Intramural)
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Chemical References |
- Antigens, Bacterial
- Bacterial Outer Membrane Proteins
- OspC protein
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Topics |
- Animals
- Antigens, Bacterial
(genetics)
- Bacterial Outer Membrane Proteins
(genetics)
- Borrelia burgdorferi
(genetics, growth & development, immunology)
- Gene Deletion
- Immunity, Innate
(genetics)
- Lyme Disease
(immunology, microbiology, transmission)
- Mice
- Mice, Inbred C3H
- Skin Diseases, Bacterial
(immunology, microbiology, transmission)
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