Abstract | OBJECTIVE: STUDY DESIGN: We administered vitamin D(2), 50,000 IU orally to 16 Nigerian children 15 to 48 months of age with radiographically active rickets. We measured calcium and vitamin D metabolites at baseline and at 1, 3, 7, and 14 days. RESULTS: At baseline, ranges of serum 25-hydroxyvitamin D (25( OH)D) concentrations were 18 to 40 nmol/L (7-16 ng/mL), and 1,25-dihydroxyvitamin D (1,25-(OH)(2)D) concentrations were 290 to 790 pmol/L (120-330 pg/mL). After vitamin D administration, serum 25( OH)D and 1,25(OH)(2)D concentrations rapidly rose and peaked at 2.8 and 1.9 times the baseline values (P < .001), respectively, at 3 days. Positive correlations between 1,25(OH)(2)D and 25( OH)D were strongest at day 3 (r = 0.84, P < .001) and weakest at day 14 (r = 0.41, P = .11). The relationship of 1,25(OH)(2)D with 25( OH) D at baseline and the increase in 1,25(OH)(2)D in response to vitamin D were similar to those described in children with vitamin D deficiency. However, unlike the pattern in vitamin D deficiency, 1,25(OH)(2)D remained positively correlated with 25( OH)D after administration of vitamin D. CONCLUSION:
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Authors | Tom D Thacher, Philip R Fischer, Christian O Isichei, John M Pettifor |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 149
Issue 6
Pg. 840-4
(Dec 2006)
ISSN: 0022-3476 [Print] United States |
PMID | 17137904
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Ergocalciferols
- Vitamins
- Vitamin D
- 1,25-dihydroxyvitamin D
- Calcium
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Topics |
- Administration, Oral
- Calcium
(deficiency)
- Child, Preschool
- Deficiency Diseases
(drug therapy)
- Ergocalciferols
(administration & dosage)
- Female
- Humans
- Infant
- Male
- Rickets
(drug therapy)
- Time Factors
- Vitamin D
(analogs & derivatives, blood)
- Vitamins
(administration & dosage)
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