Abstract |
We measured the sequential changes in 2',5' oligoadenylate synthetase activity in 21 patients with acute viral hepatitis (5 with type A, 6 with type B, and 10 with type non-A, non-B hepatitis) by radioimmunoassay. Liver biopsies were performed during the acute phase in all patients. Among patients with acute hepatitis A and B, the 2',5' oligoadenylate synthetase levels were transiently elevated at the time of the peak alanine aminotransferase level in the patients in whom a liver biopsy showed acute hepatitis or non-specific reactive hepatitis. Of 10 patients with acute non-A, non-B hepatitis, 4 showed a similar 2',5' oligoadenylate synthetase activity pattern and liver histology to those observed in acute hepatitis A and B. In the remaining 6, the 2',5' oligoadenylate synthetase levels remained elevated for 3.5 to 6 months while the alanine aminotransferase was elevated. Liver biopsy in these patients showed chronic hepatitis. Persistent detection of raised 2',5' oligoadenylate synthetase activity levels during the acute stage of non-A, non-B hepatitis may thus be an indicator of progression of the disease.
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Authors | T Okuno, M Shindo, K Arai, M Matsumoto, M Takeda, K Kashima, Y Sokawa |
Journal | Gastroenterologia Japonica
(Gastroenterol Jpn)
Vol. 26
Issue 2
Pg. 162-9
(Apr 1991)
ISSN: 0435-1339 [Print] Japan |
PMID | 1710193
(Publication Type: Journal Article)
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Chemical References |
- Interferons
- Alanine Transaminase
- 2',5'-Oligoadenylate Synthetase
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Topics |
- 2',5'-Oligoadenylate Synthetase
(blood)
- Acute Disease
- Adult
- Alanine Transaminase
(blood)
- Biopsy
- Female
- Hepatitis A
(enzymology, pathology)
- Hepatitis B
(enzymology, pathology)
- Hepatitis C
(enzymology, pathology)
- Hepatitis, Viral, Human
(enzymology, metabolism, pathology)
- Humans
- Interferons
(biosynthesis)
- Male
- Middle Aged
- Radioimmunoassay
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