Abstract | BACKGROUND: Despite widespread use of the endoscopic technique in the treatment of inguinal and incisional hernias, knowledge about its impact on abdominal wall wound healing is rare. Questions remain regarding the risk of port-site hernias and hernia recurrence. The current study investigated the gas-dependent effects of pneumoperitoneum on laparotomy wound healing. METHODS: RESULTS: After 5 and 10 days, the percentages of CD68-positive cells, granuloma formation, and expression of MMP-8 did not differ between the groups. In contrast, after both 5 and 10 days, the expression of MMP-13 and the collagen 1 to 3 ratio were significantly higher after helium pneumoperitoneum than in the control animals. CONCLUSION: The results suggest that helium pneumoperitoneum may ameliorate wound healing within the abdominal wall and could therefore represent a beneficial gas for endoscopic hernia repair.
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Authors | R Rosch, K Junge, M Binnebösel, N Mirgartz, U Klinge, V Schumpelick |
Journal | Surgical endoscopy
(Surg Endosc)
Vol. 20
Issue 12
Pg. 1892-6
(Dec 2006)
ISSN: 1432-2218 [Electronic] Germany |
PMID | 17024535
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Abdominal Wall
(pathology, surgery)
- Animals
- Disease Models, Animal
- Helium
(administration & dosage)
- Hernia, Inguinal
(surgery)
- Laparotomy
(methods)
- Male
- Pneumoperitoneum, Artificial
(methods)
- Rats
- Rats, Sprague-Dawley
- Wound Healing
(physiology)
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