Antibody persistence after primary vaccination with a hexavalent DTPa-HBV-IPV/HiB vaccine coadministered with a meningococcal C-CRM197 vaccine and response to a DTPa-IPV/HiB booster at 18 months of age.

Abstract	Children 17-20 months of age (N = 344) received a diphtheria-tetanus toxoids-acellular pertussis (DTPa)-inactivated poliovirus vaccine (IPV)/Haemophilus influenzae (Hib) booster after a 3-dose primary vaccination course with DTPa-hepatitis B vaccine-IPV/Hib plus conjugate meningococcal C vaccine-CRM. Seroprotection rates were >80% (diphtheria, tetanus, hepatitis B, polio and polyribosylribitol phosphate) before and > or =96.6% (diphtheria, tetanus, polio and polyribosylribitol phosphate) after booster vaccination. The booster was well-tolerated (fever >39.5 degrees C after <2% of doses; large swelling reactions after 6.3% of doses).
Authors	Juan-Carlos Tejedor, Félix Omeñaca, José García-Sicilia, Carlos Esporrín, Vicente Molina, Josep Marés, Marta Muro, Pilar Sanjuan, María Méndez, Roser Teixidor, Manuel Enrubia, Pilar García-Corbeira, Reyes Boceta, Jeanne-Marie Jacquet, Lode Schuerman, Spanish DTPa-IPV/Hib-049 Study Group
Journal	The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 25 Issue 10 Pg. 943-5 (Oct 2006) ISSN: 0891-3668 [Print] United States
PMID	17006294 (Publication Type: Journal Article)
Chemical References	Adjuvants, Immunologic Antibodies, Bacterial Antibodies, Viral Bacterial Proteins DT5aP-Hib-IPV vaccine Diphtheria-Tetanus-Pertussis Vaccine Hepatitis B Vaccines Meningococcal Vaccines Poliovirus Vaccine, Inactivated Vaccines, Combined serogroup C meningococcal conjugate vaccine CRM197 (non-toxic variant of diphtheria toxin)
Topics	Adjuvants, Immunologic Antibodies, Bacterial (blood) Antibodies, Viral (blood) Bacterial Proteins (administration & dosage, immunology) Diphtheria-Tetanus-Pertussis Vaccine Female Hepatitis B Vaccines (administration & dosage, immunology) Humans Immunization, Secondary Infant Male Meningococcal Vaccines (administration & dosage, immunology) Poliovirus Vaccine, Inactivated Vaccination Vaccines, Combined (administration & dosage, immunology)

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