Abstract | OBJECTIVES: METHODS: RESULTS: After a median follow up of 33.5 months, we found six patients (group A) who had hypogammaglobulinemia, while the eight other patients (group B) had normal serum immunoglobulin levels. A phenotypical analysis revealed that group A patients had already achieved B-cell recovery. However, we found a severe delay in the recovery of CD27+ memory B cells, especially in the IgD-/CD27+ switched populations in group A, but CD27 negative naive B-cells reverted to a normal range in both groups. Consistent with this, reverse transcriptase-polymerase chain reaction studies with peripheral blood mononuclear cells revealed that most patients in group A lacked more than two classes of isotype transcripts. CONCLUSIONS: Abnormal repertoires and impaired isotype expression are seen in patients with common variable immunodeficiency, these data suggested that rituximab after APBSCT can affect not only the B-cell quantities, but also the recovery of the B-cell repertoires.
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Authors | Mitsufumi Nishio, Katsuya Fujimoto, Satoshi Yamamoto, Tomoyuki Endo, Toshiya Sakai, Masato Obara, Kohki Kumano, Koichiro Minauchi, Keisuke Yamaguchi, Yukari Takeda, Norihiro Sato, Kazuki Koizumi, Masaya Mukai, Takao Koike |
Journal | European journal of haematology
(Eur J Haematol)
Vol. 77
Issue 3
Pg. 226-32
(Sep 2006)
ISSN: 0902-4441 [Print] England |
PMID | 16923109
(Publication Type: Clinical Trial, Historical Article, Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Murine-Derived
- Immunoglobulin Isotypes
- Rituximab
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Topics |
- Adult
- Agammaglobulinemia
(etiology, genetics, immunology)
- Antibodies, Monoclonal
(administration & dosage, adverse effects)
- Antibodies, Monoclonal, Murine-Derived
- B-Lymphocytes
(immunology)
- Combined Modality Therapy
- Female
- History, 18th Century
- Humans
- Immunoglobulin Isotypes
(blood, genetics)
- Immunologic Memory
- Lymphoma, Non-Hodgkin
(genetics, immunology, therapy)
- Male
- Middle Aged
- Peripheral Blood Stem Cell Transplantation
- Rituximab
- Transplantation, Autologous
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