Keratin profiles may differ between intraepidermal and intradermal invasive eccrine porocarcinoma.

Abstract

We report two cases of eccrine porocarcinoma (EPC), one of intrepidermal EPC (IEEPC) and one of intradermal invasive EPC (IDEPC) in an immunohistochemical study of cytokeratins (CK) using nine different anti-keratin antibodies against CK1, 7, 8, 10, 14, 16, 17, 18 and 19. IEEPC expressed terminal differentiated CK1 and CK10. In contrast, IDEPC expressed simple-epithelial keratins such as CK7, 8, 18 and 19. Keratin expression of IEEPC preserves the immunophenotypes of normal epidermis. IDEPC, however, expresses poorly differentiated keratin. These results suggest that the keratin profiles of EPC are correlated with the invasive degree and reflect the clinical prognosis of EPC.

• Authors: Ichiro Kurokawa, Yoshiko Urakawa, Yuko Senba, Eriko Kawabata, Keisuke Nishimura, Youichi Omoto, Kazuya Tokime, Hitoshi Mizutani, Airo Tsubura
• Journal: Oncology reports (Oncol Rep) Vol. 16 Issue 3 Pg. 473-7 (Sep 2006) ISSN: 1021-335X [Print] Greece
• PMID: 16865245 (Publication Type: Case Reports, Journal Article)

Chemical References

• Keratins

Topics

• Acrospiroma (metabolism, pathology)
• Aged
• Dermis (metabolism, pathology)
• Eccrine Glands (metabolism, pathology)
• Epidermis (metabolism, pathology)
• Humans
• Immunoenzyme Techniques
• Keratins (metabolism)
• Male
• Neoplasm Invasiveness (pathology)
• Sweat Gland Neoplasms (diagnosis, metabolism)