Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV.

Abstract

In contrast to Yersinia pestis LcrV, the recombinant V10 (rV10) variant (lacking residues 271 to 300) does not suppress the release of proinflammatory cytokines by immune cells. Immunization with rV10 generates robust antibody responses that protect mice against bubonic plague and pneumonic plague, suggesting that rV10 may serve as an improved plague vaccine.

• Authors: Kristin L DeBord, Deborah M Anderson, Melanie M Marketon, Katie A Overheim, R William DePaolo, Nancy A Ciletti, Bana Jabri, Olaf Schneewind
• Journal: Infection and immunity (Infect Immun) Vol. 74 Issue 8 Pg. 4910-4 (Aug 2006) ISSN: 0019-9567 [Print] United States
• PMID: 16861680 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Antibodies, Bacterial
• Antigens, Bacterial
• LcrV protein, Yersinia
• Plague Vaccine
• Pore Forming Cytotoxic Proteins
• Recombinant Proteins

Topics

• Animals
• Antibodies, Bacterial (blood)
• Antigens, Bacterial (administration & dosage, genetics, immunology)
• Mice
• Mice, Inbred BALB C
• Plague (immunology, mortality, prevention & control)
• Plague Vaccine (administration & dosage, immunology)
• Pore Forming Cytotoxic Proteins
• Recombinant Proteins (administration & dosage, immunology)
• Vaccination
• Yersinia pestis (immunology)