Abstract | OBJECTIVE: To investigate whether ghrelin concentrations and their changes during weight loss in obese children are associated with parameters of glucose and insulin metabolism. DESIGN: SETTING: In-patient rehabilitation program in a pediatric hospital. PARTICIPANTS: Twenty-three obese children (age 10-16 years) and 11 normal weight controls (age 10-15 years). OUTCOME MEASURES: RESULTS:
Weight loss increased the area under the curve (AUC) of ghrelin by 26% (P<0.001). The increase in ghrelin AUC correlated significantly with improved estimated insulin sensitivity (WBISI) (r=0.69, P<0.001). The independent predicting effect of WBISI was confirmed in multivariate analysis. In children with low WBISI, ghrelin reached the level of control values after weight loss. In children with high WBISI, ghrelin increased markedly above control levels. CONCLUSIONS: Changes in ghrelin are independently associated with changes in glucose and insulin metabolism. The increase in plasma ghrelin above control levels was limited to obese children with high WBISI.
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Authors | K Krohn, C Boczan, B Otto, W Heldwein, R Landgraf, C P Bauer, B Koletzko |
Journal | International journal of obesity (2005)
(Int J Obes (Lond))
Vol. 30
Issue 10
Pg. 1482-7
(Oct 2006)
ISSN: 0307-0565 [Print] England |
PMID | 16801928
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Ghrelin
- Insulin
- Peptide Hormones
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Topics |
- Adolescent
- Blood Glucose
(metabolism)
- Body Composition
- Body Mass Index
- Body Weight
- Child
- Female
- Ghrelin
- Glucose Tolerance Test
- Humans
- Insulin
(blood)
- Insulin Resistance
- Male
- Obesity
(blood, diet therapy, physiopathology)
- Peptide Hormones
(blood, physiology)
- Weight Loss
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