IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance.

Abstract

OBJECTIVE:

IGF-binding protein (IGFBP)-1 is negatively regulated by insulin. We determined whether the measurement of IGFBP-1 in serum is a useful marker of insulin resistance.

RESEARCH DESIGN AND METHODS:

Twenty-three subjects underwent a euglycemic insulin clamp. Glucose disposal rates (M) were then correlated with measurements of IGFBP-1, fasting insulin levels, homeostasis model assessment (HOMA), and BMI.

RESULTS:

IGFBP-1 levels more strongly correlated with M (R = 0.73) than the other parameters such as BMI or HOMA. The level of this protein decreased in individuals who became more insulin sensitive by exercise training.

CONCLUSIONS:

These studies show a strong correlation between insulin sensitivity and the serum levels of IGFBP-1. These studies suggest, therefore, that measurement of this protein may be valuable in identifying those individuals with insulin resistance and those individuals who respond to interventional strategies.

• Authors: Betty A Maddux, Adelene Chan, Elena A De Filippis, Lawrence J Mandarino, Ira D Goldfine
• Journal: Diabetes care (Diabetes Care) Vol. 29 Issue 7 Pg. 1535-7 (Jul 2006) ISSN: 0149-5992 [Print] United States
• PMID: 16801575 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Biomarkers
• Blood Glucose
• Insulin
• Insulin-Like Growth Factor Binding Protein 1

Topics

• Adult
• Biomarkers (blood)
• Blood Glucose (metabolism)
• Female
• Glucose Tolerance Test
• Humans
• Insulin (physiology)
• Insulin Resistance (physiology)
• Insulin-Like Growth Factor Binding Protein 1 (blood)
• Male
• Middle Aged