Intracoronary injection of granulocyte colony-stimulating factor ameliorates the progression of left ventricular remodeling after myocardial ischemia/reperfusion in rabbits.

Abstract

BACKGROUND:

Although granulocyte colony-stimulating factor (G-CSF) is known to prevent left ventricular (LV) remodeling after acute myocardial infarction (AMI), the best method of administration is unknown.

METHODS AND RESULTS:

A rabbit ischemia/reperfusion model was created and G-CSF was administered into the coronary artery immediately after reperfusion. The LV size and contraction were determined by echocardiography, and the extent of infarcted myocardium was measured by Masson-Trichrome staining. The benefits of intracoronary injection of G-CSF on LV remodeling were similar to subcutaneous injection.

CONCLUSIONS:

Direct intracoronary G-CSF injection may become a new therapy for AMI with lower adverse effects.

• Authors: Hiroshi Hasegawa, Hiroyuki Takano, Hirokazu Shiraishi, Kazutaka Ueda, Yuriko Niitsuma, Hiroyuki Tadokoro, Issei Komuro
• Journal: Circulation journal : official journal of the Japanese Circulation Society (Circ J) Vol. 70 Issue 7 Pg. 942-4 (Jul 2006) ISSN: 1346-9843 [Print] Japan
• PMID: 16799254 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Recombinant Proteins
• Granulocyte Colony-Stimulating Factor

Topics

• Acute Disease
• Animals
• Disease Models, Animal
• Echocardiography
• Granulocyte Colony-Stimulating Factor (administration & dosage)
• Injections, Subcutaneous
• Male
• Myocardial Reperfusion Injury (complications)
• Rabbits
• Recombinant Proteins
• Ventricular Remodeling (drug effects)