Maturity-onset diabetes of the young with necrobiosis lipoidica and granuloma annulare.

Abstract

We describe a 12-year-old white girl with granuloma annulare localized to both ankles since she was five, necrobiosis lipoidica in the left pretibial region since she was ten, and a recent history of weakness, migraine, and weight loss. After initial evaluation, high fasting blood glucose levels and high hemoglobin A1c were found. The family history for non-insulin-dependent diabetes was suggestive of maturity-onset diabetes of the young. Coexistence of necrobiosis lipoidica and granuloma annulare, together with a family history of non-insulin-dependent diabetes, the age of onset, and the absence of ketosis, are specific features making possible, a clinical diagnosis. Genetic confirmation may not be so easily accessible or necessary.

• Authors: Federico Marchetti, Tania Gerarduzzi, Filippo Longo, Elena Faleschini, Alessandro Ventura, Giorgio Tonini
• Journal: Pediatric dermatology (Pediatr Dermatol) 2006 May-Jun Vol. 23 Issue 3 Pg. 247-50 ISSN: 0736-8046 [Print] United States
• PMID: 16780472 (Publication Type: Case Reports, Journal Article)

Topics

• Child
• Diabetes Mellitus, Type 2 (complications, diagnosis, genetics)
• Female
• Granuloma Annulare (etiology)
• Humans
• Necrobiosis Lipoidica (etiology)