Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study.

Abstract

In mouse models, apolipoprotein A-V (apoA-V) exhibits triglyceride (TG)-lowering effects. We investigated the apoA-V/TG relationship and the association of apoA-V with coronary artery disease (CAD) risk by determining serum apoA-V levels and genotypes in a nested case-control (n = 1,034/2,031) study. Both univariate and multivariate apoA-V levels showed no association with future CAD (P = 0.4 and 0.5, respectively). Unexpectedly, there was a significant positive correlation between serum apoA-V and TG in men and women (r = 0.36 and 0.28, respectively, P < 0.001 each) but a negative correlation between apoA-V and LPL mass (r = -0.14 and -0.12 for men and women respectively, P < 0.001 each). The frequency of the c.56C>G polymorphism did not differ between cases and controls despite significant positive association of c.56G with both apoA-V and TG levels. For -1131T>C, the minor allele was significantly associated with lower apoA-V yet higher TG levels and was overrepresented in cases (P = 0.047). The association of -1131T>C with CAD risk, however, was independent of apoA-V levels and likely acts through linkage disequilibrium with APOC3 variants. The positive correlation of apoA-V levels with TG levels, negative correlation with LPL levels, and lack of association with CAD risk highlight the need for further human studies to clarify the role of apoA-V.

• Authors: Stefan F C Vaessen, Frank G Schaap, Jan-Albert Kuivenhoven, Albert K Groen, Barbara A Hutten, S Matthijs Boekholdt, Hiroaki Hattori, Manjinder S Sandhu, Sheila A Bingham, Robert Luben, Jutta A Palmen, Nicholas J Wareham, Steve E Humphries, John J P Kastelein, Philippa J Talmud, Kay-Tee Khaw
• Journal: Journal of lipid research (J Lipid Res) Vol. 47 Issue 9 Pg. 2064-70 (Sep 2006) ISSN: 0022-2275 [Print] United States
• PMID: 16769999 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• APOA5 protein, human
• Apolipoprotein A-V
• Apolipoproteins
• Apolipoproteins A
• Triglycerides

Topics

• Aged
• Apolipoprotein A-V
• Apolipoproteins (blood, genetics)
• Apolipoproteins A
• Case-Control Studies
• Coronary Artery Disease (blood, genetics)
• Female
• Gene Frequency (genetics)
• Genotype
• Humans
• Linkage Disequilibrium (genetics)
• Male
• Middle Aged
• Multivariate Analysis
• Polymorphism, Single Nucleotide (genetics)
• Prospective Studies
• Risk Factors
• Triglycerides (blood)
• United Kingdom