Animal models of spondyloarthritis.

Abstract

PURPOSE OF REVIEW:

The aim of this article is to review new insights into spondyloarthritis obtained in animal models during the last year.

RECENT FINDINGS:

HLA-B27 misfolding has been demonstrated in HLA-B27/human beta2-microglobulin transgenic rats. HLA-B27 misfolding is associated with a typical unfolded protein stress response and with an interferon-response signature. Prebiotic treatment of these rats reduced colitis and arthritis. Proteoglycan-induced spondylitis is distinct from proteoglycan-induced arthritis. Specific susceptibility loci for proteoglycan-induced spondylitis have been demonstrated. Bone morphogenetic proteins are important in new cartilage and bone formation in ankylosing enthesitis. Psoriasis and psoriatic arthritis-like disease develops in conditional double JunB/c-Jun knockout mice.

SUMMARY:

Insights into the molecular signaling pathways driving HLA-B27 associated spondylitis, autoimmune spondylitis, ankylosing enthesitis and psoriasis, resulting from animal models, identify new and specific therapeutic targets in spondyloarthritis.

• Authors: Rik J U Lories
• Journal: Current opinion in rheumatology (Curr Opin Rheumatol) Vol. 18 Issue 4 Pg. 342-6 (Jul 2006) ISSN: 1040-8711 [Print] United States
• PMID: 16763452 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• HLA-B Antigens

Topics

• Animals
• Disease Models, Animal
• Genes, jun
• HLA-B Antigens (immunology)
• Humans
• Mice
• Mice, Knockout
• Psoriasis (genetics)
• Spondylitis, Ankylosing (genetics, immunology)