Inhibitory effect of isoprenoid-substituted flavonoids isolated from Artocarpus heterophyllus on melanin biosynthesis.

Abstract

Isoprenoid-substituted flavonoids were isolated from the wood of Artocarpus heterophyllus by means of activity-guided fractionation. Artocarpin (1), cudraflavone C (2), 6-prenylapigenin (3), kuwanon C (4), norartocarpin (5) and albanin A (6) inhibited melanin biosynthesis in B16 melanoma cells without inhibiting tyrosinase. A structure-activity investigation indicated that the presence of the isoprenoid-substituted moiety enhanced the inhibitory activity on melanin production in B16 melanoma cells.

• Authors: Enos Tangke Arung, Kuniyoshi Shimizu, Ryuichiro Kondo
• Journal: Planta medica (Planta Med) Vol. 72 Issue 9 Pg. 847-50 (Jul 2006) ISSN: 0032-0943 [Print] Germany
• PMID: 16732541 (Publication Type: Journal Article)

Chemical References

• Flavonoids
• Melanins
• Plant Extracts
• Terpenes
• Monophenol Monooxygenase

Topics

• Animals
• Artocarpus (chemistry)
• Cell Line, Tumor
• Chemical Fractionation
• Flavonoids (chemistry, isolation & purification, pharmacology)
• Melanins (biosynthesis)
• Melanoma, Experimental
• Monophenol Monooxygenase (metabolism)
• Plant Extracts (chemistry, isolation & purification, pharmacology)
• Structure-Activity Relationship
• Terpenes (chemistry, isolation & purification, pharmacology)