Genetic linkage of autosomal recessive canine narcolepsy with a mu immunoglobulin heavy-chain switch-like segment.

Abstract

Identification of genes determining narcolepsy susceptibility is important not only for understanding that disorder but also for possible clues to general sleep-control mechanisms. Studies in humans reveal at least one such gene related to the major histocompatibility complex and in dog an as-yet-unmapped single, autosomal recessive gene canarc-1. Gene markers for canarc-1 were therefore sought by DNA restriction fragment length polymorphisms in our colony of narcoleptic dogs. A human mu-switch immunoglobulin probe and the enzyme Hae III identified a gene cosegregating with canarc-1 in backcrossed animals (logarithm of odds scores: m = 24, Z max = 7.2 at theta = 0%). canarc-1 was also shown not to be tightly linked with the dog major histocompatibility complex (m = 40, Z less than -2 at theta less than 4.8%). These results represent the mapping of a non-major histocompatibility complex narcolepsy gene and strongly suggest involvement of the immune system in the pathophysiology of that disease.

• Authors: E Mignot, C Wang, C Rattazzi, C Gaiser, M Lovett, C Guilleminault, W C Dement, F C Grumet
• Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 88 Issue 8 Pg. 3475-8 (Apr 15 1991) ISSN: 0027-8424 [Print] United States
• PMID: 1673032 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Immunoglobulin mu-Chains

Topics

• Animals
• Dog Diseases (genetics)
• Dogs
• Genes, Immunoglobulin
• Genes, Recessive
• Genes, Switch
• Genetic Linkage
• Immunoglobulin mu-Chains (genetics)
• Major Histocompatibility Complex
• Narcolepsy (genetics, veterinary)
• Pedigree
• Polymorphism, Restriction Fragment Length