Abstract | PURPOSE: METHODS: RESULTS: Data were collected on 16 patients and a total of 93 treatment visits. Average total dosage was 3,633 U per treatment session. Mean duration of beneficial effect was 7.3 weeks and was most commonly rated as fair to excellent. Side effects for botulinum toxin B occurred at a higher rate than is typical for botulinum toxin A. Most common side effects were pain on injection (100%), ptosis (32.3%), facial or mouth droop (22.6%), dry mouth (17.2%), dry eye (9.7%), exposure keratitis (7.5%), and blurred vision (5.4%). The rate of occurrence of side effects appears to be dose-dependent. CONCLUSIONS:
Botulinum toxin B is a useful treatment for cases that have become refractory to botulinum toxin A. The duration of beneficial effect is shorter than for type A. The side effect profile is similar to that for toxin type A except for pain on injection and the occurrence of dry mouth. Side effects occurred at a higher frequency than with botulinum toxin A, and the pattern suggests that botulinum toxin B spreads more diffusely. Side effects appear to be dosage-related.
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Authors | Jonathan J Dutton, Jeffrey J White, Michael J Richard |
Journal | Ophthalmic plastic and reconstructive surgery
(Ophthalmic Plast Reconstr Surg)
2006 May-Jun
Vol. 22
Issue 3
Pg. 173-7
ISSN: 0740-9303 [Print] United States |
PMID | 16714924
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- rimabotulinumtoxinB
- Botulinum Toxins
- Botulinum Toxins, Type A
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Topics |
- Aged
- Blepharospasm
(drug therapy)
- Botulinum Toxins
(administration & dosage, adverse effects, therapeutic use)
- Botulinum Toxins, Type A
(therapeutic use)
- Drug Resistance
- Female
- Humans
- Male
- Middle Aged
- Prospective Studies
- Treatment Outcome
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