The treatment of refractory pneumothorax in diffuse panbronchiolitis by intravenous administration of coagulation factor XIII concentrate.

Abstract

This case report presents a patient with advanced diffuse panbronchiolitis accompanied by chronic respiratory failure, marked cachexia, and refractory spontaneous pneumothorax. Because instillation of a pleurodesis agent and thoracoscopy were considered highly risky and invasive, we instead treated the patient with intravenous administration of a coagulation factor XIII concentrate, and the pneumothorax resolved. This case suggests refractory pneumothorax in a restrictive ventilatory disorder can be effectively treated with noninvasive intravenous administration of coagulation factor XIII concentrate.

• Authors: Akira Murata, Ayumi Kouno, Kazuo Yamamoto, Hiroko Yoshioka, Kozui Kida, Shoji Kudoh
• Journal: Journal of Nippon Medical School = Nippon Ika Daigaku zasshi (J Nippon Med Sch) Vol. 73 Issue 2 Pg. 89-92 (Apr 2006) ISSN: 1345-4676 [Print] Japan
• PMID: 16641533 (Publication Type: Case Reports, Journal Article)

Chemical References

• Factor XIII

Topics

• Bronchiolitis (complications)
• Factor XIII (administration & dosage, therapeutic use)
• Female
• Humans
• Injections, Intravenous
• Middle Aged
• Pneumothorax (drug therapy)