Clearance of xenon-133 from bone marrow in patients with small-cell lung cancer.

Abstract

The aim of this study was to estimate bone-marrow blood flow (BMBF) in man and to correlate this with myelosuppression induced by cytostatic treatment dosed as a function of surface area. Twenty-four patients suffering from small-cell lung cancer participated in the study. Blood flow was measured with the xenon-133 washout technique. The 133Xe clearance measurement took place in conjunction with the pre-treatment bone-marrow staging procedure (ad modern Radner). Tissue samples were taken for microscopy and for the determination of the blood-to-tissue partition coefficient lambda. After the bone-marrow aspiration, 0.1-0.2 ml of 133Xe in saline was injected into the bone marrow and the cannula was removed. Following a hyperaemic phase of 12 min (7-16 min), monoexponential washouts were demonstrated. The median washout rate constant was 0.0063 min-1 (0.0038-0.0098 min-1). Lambda values of 0.3-3.5 ml g were found, but microscopy of the bone marrow showed a fairly large admixture of peripheral blood. Therefore, the lambda values should be taken with caution and absolute blood-flow values were not calculated. The results demonstrated no correlation between 133Xe clearance from crista iliaca and leucocyte or platelet suppression.

• Authors: L J Petersen, L Friberg, J Jensen, J Bülow, M Hansen, J Madsen
• Journal: Scandinavian journal of clinical and laboratory investigation (Scand J Clin Lab Invest) Vol. 51 Issue 6 Pg. 559-63 (Oct 1991) ISSN: 0036-5513 [Print] England
• PMID: 1662828 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Xenon Radioisotopes

Topics

• Aged
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Bone Marrow (blood supply, metabolism)
• Carcinoma, Small Cell (drug therapy, metabolism)
• Female
• Humans
• Leukocyte Count (drug effects)
• Lung Neoplasms (drug therapy, metabolism)
• Male
• Middle Aged
• Platelet Count (drug effects)
• Regional Blood Flow (physiology, radiation effects)
• Regression Analysis
• Xenon Radioisotopes (pharmacokinetics)