AlOH3-adjuvanted vaccine-induced macrophagic myofasciitis in rats is influenced by the genetic background.

Abstract

Macrophagic myofasciitis (MMF) is a specific histopathologic lesion involved in the persistence for years of aluminum hydroxide [Al(OH)(3)] at the site of previous intramuscular (i.m.) injection. In order to study mechanisms involved persistence of MMF lesions, we set up an experimental model of MMF-lesion in Sprague-Dawley and Lewis rat, by i.m. injections of 10 microL of an Al(OH)(3)-adjuvanted vaccine. An evaluation carried out over a 12-month period disclosed significant shrinkage of MMF lesions with time. A radioisotopic study did not show significant aluminium uptake by Al(OH)(3)-loaded macrophages. A morphometric approach showed that Lewis rats with Th1-biased immunity had significantly smaller lesions than Sprague-Dawley rats with balanced Th1/Th2 immunity. Concluding, our results indicate that genetic determinatives of cytotoxic T-cell responses could interfere with the clearance process and condition the persistence of vaccine-induced MMF-lesions.

• Authors: François-Jérôme Authier, Stéphane Sauvat, Christo Christov, Patrick Chariot, Grant Raisbeck, Marie-Françoise Poron, Françoise Yiou, Romain Gherardi
• Journal: Neuromuscular disorders : NMD (Neuromuscul Disord) Vol. 16 Issue 5 Pg. 347-52 (May 2006) ISSN: 0960-8966 [Print] England
• PMID: 16616846 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Vaccines
• Aluminum Hydroxide

Topics

• Aluminum Hydroxide (adverse effects)
• Animals
• Disease Models, Animal
• Female
• Genetic Predisposition to Disease (genetics)
• Immunity, Cellular (drug effects, immunology)
• Injections, Intramuscular (adverse effects)
• Macrophages (drug effects, immunology)
• Muscle, Skeletal (drug effects, immunology, pathology)
• Myofascial Pain Syndromes (chemically induced, genetics, physiopathology)
• Rats
• Rats, Inbred Lew
• Rats, Sprague-Dawley
• T-Lymphocytes, Cytotoxic (drug effects, immunology)
• Th1 Cells (drug effects, immunology)
• Th2 Cells (drug effects, immunology)
• Vaccines (adverse effects)