p53 protein or BID protein select the route to either apoptosis (programmed cell death) or to cell cycle arrest opposing carcinogenesis after DNA damage by ROS.

Abstract

p53 is a tumour-suppressor protein of human cells that prevents their entry into the route to carcinogenesis. Furthermore, p53 protein acts at the p53-response loci in genomic DNA to facilitate the switch-on of genes that can be expressed by the biosynthesis of routing-proteins for apoptosis or stalling of cellular proliferation (via cell cycle progression checkpoint arrests). Moreover, oxidative stress by reactive oxygen species (ROS) such as the hydroxyl radical (*OH) produced by ionizing radiation (carcinogenic) triggers p53 activation in response to the damage of DNA (followed by initiation of DNA-repair mechanisms). Phosphorylation of the BID protein may lead to the recovery from DNA-damage by ROS.

• Authors: Alan Wiseman
• Journal: Medical hypotheses (Med Hypotheses) Vol. 67 Issue 2 Pg. 296-9 ( 2006) ISSN: 0306-9877 [Print] United States
• PMID: 16580789 (Publication Type: Journal Article)

Chemical References

• BH3 Interacting Domain Death Agonist Protein
• BID protein, human
• Reactive Oxygen Species
• Tumor Suppressor Protein p53

Topics

• Apoptosis
• BH3 Interacting Domain Death Agonist Protein (metabolism, physiology)
• Cell Cycle
• Cell Transformation, Neoplastic (genetics)
• DNA Damage
• DNA Repair
• Humans
• Oxidative Stress
• Phosphorylation
• Reactive Oxygen Species (metabolism)
• Tumor Suppressor Protein p53 (physiology)