[A case of aged recurrent breast cancer with multiple lung metastases responding to examestane monotherapy].

Abstract

An 85-year-old woman suffering from an angina attack was admitted to our hospital, and diagnosed with multiple lung metastases by CT scan. Because she was extremely aged with a long disease-free period of over 12 years, and without any life-threatening state despite multiple lung metastases, she received hormonal therapy. Examestane was considered one of the most-effective hormonal drugs for metastatic breast cancer. The efficacy of the treatment was definite: the multiple metastatic lesions showed a partial response after 5 months'treatment, and reached a complete response after 10 months'treatment. After 8 months in the complete response state, CT scan revealed progressive disease. Fortunately, the lung metastatic lesions were only slowly progressive, and she has no symptoms now. There was no side effect except for complication of subdural hematoma. Examestane is considered highly effective for metastatic breast cancer and well tolerated by an aged patient like this case.

• Authors: Shigeru Imamura, Masakazu Aso, Hisanobu Sakata, Hidenori Katoh
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 33 Issue 3 Pg. 361-4 (Mar 2006) ISSN: 0385-0684 [Print] Japan
• PMID: 16531719 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents, Hormonal
• Aromatase Inhibitors

Topics

• Aged, 80 and over
• Antineoplastic Agents, Hormonal (therapeutic use)
• Aromatase Inhibitors (therapeutic use)
• Breast Neoplasms (drug therapy, pathology, surgery)
• Carcinoma, Ductal, Breast (drug therapy, secondary, surgery)
• Drug Administration Schedule
• Female
• Humans
• Lung Neoplasms (drug therapy, secondary)
• Mastectomy, Radical
• Remission Induction