Abstract | PURPOSE OF REVIEW: The treatment of patients with advanced non-small cell lung cancer has changed considerably in the past decade. This paper reviews the most significant changes seen in chemotherapy and the most promising new agents in development for this disease. RECENT FINDINGS: SUMMARY: Management of non-small cell lung cancer has improved considerably in the past decade. The overall benefit of chemotherapy over supportive care has been shown, platinum-based doublets have been established, nonplatinum regimens have been developed, chemotherapy has been used more broadly in subgroups of patients who have been previously neglected, and a shorter chemotherapy duration has been shown to be equally effective. After hitting a plateau in the benefit of chemotherapy, new drugs with novel action mechanisms such as the ones described here offer hope to improve therapy for this disease.
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Authors | Luis E Raez, Rogerio Lilenbaum |
Journal | Current opinion in oncology
(Curr Opin Oncol)
Vol. 18
Issue 2
Pg. 156-61
(Mar 2006)
ISSN: 1040-8746 [Print] United States |
PMID | 16462185
(Publication Type: Journal Article, Review)
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Chemical References |
- Antineoplastic Agents
- Boronic Acids
- Epothilones
- Glutamates
- Organoplatinum Compounds
- Pyrazines
- Pemetrexed
- Oxaliplatin
- TER 286
- Guanine
- Bortezomib
- Glutathione
- Paclitaxel
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Topics |
- Antineoplastic Agents
(therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Boronic Acids
(therapeutic use)
- Bortezomib
- Carcinoma, Non-Small-Cell Lung
(drug therapy)
- Clinical Trials as Topic
- Epothilones
(therapeutic use)
- Glutamates
(therapeutic use)
- Glutathione
(analogs & derivatives, therapeutic use)
- Guanine
(analogs & derivatives, therapeutic use)
- Humans
- Lung Neoplasms
(drug therapy)
- Organoplatinum Compounds
(therapeutic use)
- Oxaliplatin
- Paclitaxel
(therapeutic use)
- Pemetrexed
- Pyrazines
(therapeutic use)
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