[Successful treatment with drainage of hematoma and chemotherapy in a case of Burkitt leukemia presenting with subdural hematoma].

Abstract

A 53-year-old male was admitted because of pancytopenia and chronic subdural hematoma. Bone marrow was hypercellular with 97% blasts, which expressed CD10, CD19, CD20, and immunoglobulin mu and gamma chains on the cell surface and had chromosomal abnormalities including t(8 ; 22)(q24 ; q11). The patient was diagnosed as having Burkitt leukemia. Because hemiplegia and disturbance of consciousness developed rapidly, the patient was treated with an emergency drainage operation followed by Hyper-CVAD therapy and achieved a sustained complete remission. Dural infiltration of leukemic cells as well as thrombocytopenia was implicated in the pathogenesis of the subdural hematoma, which contained numerous blasts.

• Authors: Asako Kitano, Koh Yamamoto, Toshikage Nagao, Minako Yoshida, Tetsuya Kurosu, Ayako Arai, Tohru Miki, Naomi Murakami, Osamu Miura
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 46 Issue 4 Pg. 278-80 (Apr 2005) ISSN: 0485-1439 [Print] Japan
• PMID: 16444961 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Vincristine
• Dexamethasone
• Doxorubicin
• Cyclophosphamide

Topics

• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Burkitt Lymphoma (complications, therapy)
• Chronic Disease
• Cyclophosphamide (administration & dosage)
• Dexamethasone (administration & dosage)
• Doxorubicin (administration & dosage)
• Drainage
• Hematoma, Subdural (etiology, therapy)
• Humans
• Male
• Middle Aged
• Remission Induction
• Thrombocytopenia (complications)
• Treatment Outcome
• Vincristine (administration & dosage)