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Effect of blood alcohol level on recovery from severe closed head injury.

Abstract
A retrospective archival study of 129 moderate to severe closed head-injury patients from a university-based rehabilitation hospital was conducted to investigate the effect of blood alcohol level (BAL) at time of trauma on the length of post-traumatic amnesia (PTA), length of hospitalization and cognitive status on clearing PTA. While no statistical significance was obtained for the effect of BAL on length of PTA, a mean difference of 15.4 days between 'no alcohol' and 'intoxicated' patient groups was observed. A low, but significant correlation, r = 0.249, p less than 0.05, indicated that as blood alcohol level increased, time to rehabilitation admission increased. The sex of the patient had a significant effect on length of PTA, BAL and time of recovery variable F (6,81) = 2.468, p less than 0.05. Females experienced longer length of PTA, but had lower BALs than males. Measures of cognitive status on clearing PTA did not show a statistically significant effect of BAL. Results are discussed in terms of mediating variables in the relationship between BAL and the length of acute hospitalization, prolonged PTA in patients with a positive BAL, and potential physiological bases for the interaction among sex, BAL and PTA duration.
AuthorsC P Kaplan, J D Corrigan
JournalBrain injury (Brain Inj) 1992 Jul-Aug Vol. 6 Issue 4 Pg. 337-49 ISSN: 0269-9052 [Print] England
PMID1638267 (Publication Type: Journal Article)
Chemical References
  • Ethanol
Topics
  • Adult
  • Alcohol Amnestic Disorder (physiopathology, psychology, rehabilitation)
  • Alcoholism (physiopathology, psychology, rehabilitation)
  • Ethanol (pharmacokinetics)
  • Female
  • Follow-Up Studies
  • Head Injuries, Closed (physiopathology, psychology, rehabilitation)
  • Humans
  • Length of Stay
  • Male
  • Neurologic Examination (drug effects)
  • Neuropsychological Tests
  • Psychomotor Agitation (physiopathology, psychology, rehabilitation)
  • Rehabilitation Centers
  • Retrospective Studies

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