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Clinical effect of gatifloxacin, 200 mg daily, on bacterial community-acquired pneumonia in the elderly.

Abstract
The clinical effect of gatifloxacin (GFLX) at 200 mg daily (half of common dosage) on bacterial community-acquired pneumonia in the elderly was examined. Subjects were 30 patients with bacterial community-acquired pneumonia aged 65 years or more (mild, 21 patients; moderate, 9 patients), and GFLX at 100 mg per dose was administered twice daily for 4-14 days. The results included clinical effectiveness in 21 of 21 mildly affected patients (efficacy rate, 100%), in 8 of 9 moderately affected patients (efficacy rate, 88.9%), and 29 of a total of 30 patients (efficacy rate, 96.7%). With regard to bacteriological effect, 28 of 29 strains were eradicated (eradication rate, 96.6%). Abnormal laboratory findings included mild elevations in GPT, GOT, and ALP in only 1 patient. Based on these findings, we concluded that administration of GFLX at 200 mg daily is recommended for bacterial community-acquired pneumonia in the elderly.
AuthorsNiro Okimoto, Takashi Kibayashi, Kimihiro Mimura, Kenji Yamato, Takeyuki Kurihara, Yoshihiro Honda, Kohichi Osaki, Naoko Asaoka, Hideo Ohba
JournalJournal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (J Infect Chemother) Vol. 11 Issue 6 Pg. 274-7 (Dec 2005) ISSN: 1341-321X [Print] Netherlands
PMID16369733 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Anti-Infective Agents
  • Fluoroquinolones
  • Gatifloxacin
Topics
  • Aged
  • Aged, 80 and over
  • Anti-Infective Agents (administration & dosage, adverse effects, therapeutic use)
  • Community-Acquired Infections (drug therapy, microbiology)
  • Female
  • Fluoroquinolones (administration & dosage, adverse effects, therapeutic use)
  • Gatifloxacin
  • Gram-Negative Bacteria (drug effects)
  • Gram-Positive Bacteria (drug effects)
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Pneumonia, Bacterial (drug therapy, microbiology)
  • Severity of Illness Index
  • Treatment Outcome

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