Risk of developing fibroadenoma with the use of cyclosporine A in renal transplant recipients.

Abstract

To investigate the effect of cyclosporine A (Cyc A) on the development of fibroadenomas, 30 renal transplant patients and 20 chronic renal failure patients on dialysis were breast examined with ultrasonography and/or mammography. Of the renal transplant patients, 17 were receiving Cyc A-based combination therapy for immunosuppression. All patients were female with the age range of 29.7+/-9.2 years in the transplant group and 33.95+/-9.91 in the dialysis group. Eight of the 17 patients receiving Cyc A had fibroadenomas, 5 of them having bilateral lesions. None of the other patients, those on dialysis and on non-Cyc A combination therapy had fibroadenomas. A significant difference for fibroadenoma incidence in patients receiving Cyc A combination immunosuppression was found.

• Authors: Figen Binokay, Mustafa Balal, Erkan Demir, Saime Paydas, Sureyya Soyupak, Yasar Sertdemir, Erol Akgul
• Journal: Renal failure (Ren Fail) Vol. 27 Issue 6 Pg. 721-5 ( 2005) ISSN: 0886-022X [Print] England
• PMID: 16350824 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Immunosuppressive Agents
• Cyclosporine

Topics

• Adult
• Biopsy, Needle
• Breast Neoplasms (chemically induced, epidemiology, pathology)
• Cross-Sectional Studies
• Cyclosporine (adverse effects, therapeutic use)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Female
• Fibroadenoma (chemically induced, epidemiology, pathology)
• Follow-Up Studies
• Humans
• Immunohistochemistry
• Immunosuppressive Agents (adverse effects, therapeutic use)
• Incidence
• Kidney Failure, Chronic (diagnosis, therapy)
• Kidney Transplantation (adverse effects, immunology, methods)
• Renal Dialysis (adverse effects, methods)
• Risk Assessment
• Transplantation Immunology (physiology)