An experimental gingivitis study to evaluate the clinical effects of a stannous fluoride dentifrice.

Abstract

PURPOSE:

A double blind, controlled, parallel group trial utilizing the experimental gingivitis model was performed on thirty young adults to evaluate the clinical effects of a 0.45% stannous fluoride dentifrice used as a slurry on dental biofilm formation and the development of gingivitis.

MATERIAL AND METHODS:

Following a thorough examination and oral prophylaxis procedures, subjects were randomly assigned to apply one of the following dentifrices twice daily over a three-week period: A) dentifrice slurry without active ingredients; B) 0.45% stannous fluoride gel; and C) Colgate Total dentifrice slurry (0.30% triclosan, 0.24% sodium fluoride, 2% copolymer).

RESULTS:

After three weeks, the stannous fluoride dentifrice significantly (p < 0.05) reduced gingivitis compared with the Colgate Total group by 39.7%. Gingival bleeding was also reduced relative to the Colgate Total group. This difference was statistically significant (P < 0.05). During the experimental period, the mean PII scores increased almost linearly in all three groups without yielding any statistically significant differences.

CONCLUSIONS:

The results of this clinical trial demonstrated that, over a three-week period, the application of a 0.45% SnF2 gel significantly inhibited the onset of gingivitis compared to Triclosan/sodium fluoride/copolymer (Colgate Total). However, neither stannous fluoride nor Triclosan/sodium fluoride/ copolymer (Colgate Total) possessed sufficient antimicrobial activity to suppress biofilm formation in the absence of regular oral hygiene practices.

• Authors: Niklaus P Lang, Elena Anton, Yvonne Gabriel, Giovanni E Salvi, Bjarni E Pjetursson, J Leslie Winston, Tao He
• Journal: Oral health & preventive dentistry (Oral Health Prev Dent) Vol. 2 Issue 4 Pg. 369-76 ( 2004) ISSN: 1602-1622 [Print] Germany
• PMID: 16296255 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Complex Mixtures
• Dentifrices
• Tin Fluorides
• Toothpastes
• hydrated silica gel-based toothpaste
• Silicic Acid
• Triclosan
• Fluorides

Topics

• Adult
• Complex Mixtures (therapeutic use)
• Dental Plaque (prevention & control)
• Dental Plaque Index
• Dentifrices (therapeutic use)
• Double-Blind Method
• Female
• Fluorides (therapeutic use)
• Gingivitis (prevention & control)
• Humans
• Male
• Periodontal Index
• Silicic Acid
• Tin Fluorides (therapeutic use)
• Toothpastes
• Triclosan (therapeutic use)