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Effect of cetrorelix acetate on apoptosis and apoptosis regulatory factors in cultured uterine leiomyoma cells.

Abstract
This report suggests the possibility that a gonadotropin-releasing hormone (GnRH) antagonist initiates apoptosis not only by causing a sex hormone deficit by inhibiting GnRH secretion in the pituitary gland, but also by acting directly on leiomyoma cells promoting apoptosis.
AuthorsJa-Young Kwon, Ki-Hyun Park, Young-Nyun Park, Nam-Hoon Cho
JournalFertility and sterility (Fertil Steril) Vol. 84 Issue 5 Pg. 1526-8 (Nov 2005) ISSN: 1556-5653 [Electronic] United States
PMID16275262 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Gonadotropin-Releasing Hormone
  • cetrorelix
Topics
  • Adult
  • Apoptosis (drug effects, physiology)
  • Female
  • Gonadotropin-Releasing Hormone (analogs & derivatives, pharmacology)
  • Humans
  • Leiomyoma (metabolism, pathology)
  • Tumor Cells, Cultured
  • Uterus (drug effects, metabolism, pathology)

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