Oxidative stress is suggested to have an important role in the development of complications in diabetes. Because
ozone therapy can activate the
antioxidant system, influencing the level of glycemia and some markers of endothelial cell damage, the aim of this study was to investigate the therapeutic efficacy of
ozone in the treatment of patients with
type 2 diabetes and
diabetic feet and to compare
ozone with
antibiotic therapy. A randomized controlled clinical trial was performed with 101 patients divided into two groups: one (n = 52) treated with
ozone (local and rectal insufflation of the gas) and the other (n = 49) treated with topical and systemic
antibiotics. The efficacy of the treatments was evaluated by comparing the glycemic index, the area and perimeter of the lesions and
biochemical markers of oxidative stress and endothelial damage in both groups after 20 days of treatment.
Ozone treatment improved
glycemic control, prevented oxidative stress, normalized levels of organic
peroxides, and activated
superoxide dismutase. The pharmacodynamic effect of
ozone in the treatment of patients with neuroinfectious
diabetic foot can be ascribed to the possibility of it being a
superoxide scavenger.
Superoxide is considered a link between the four metabolic routes associated with diabetes pathology and its complications. Furthermore, the healing of the lesions improved, resulting in fewer
amputations than in control group. There were no side effects. These results show that medical
ozone treatment could be an alternative
therapy in the treatment of diabetes and its complications.