Effects of donepezil on compulsive hypersexual behavior in Parkinson disease: a single case study.

Abstract

Hypersexuality is a known, though not frequently publicized, behavioral disturbance in patients with Parkinson disease. Hypersexuality has been associated with dopaminergic drug therapy. We describe a patient with Parkinson disease who presented with compulsive hypersexual behavior. Lowering of dopaminergic drug doses was of minimal behavioral benefit but was not well tolerated because of worsening of motor function. A trial with donepezil led to significant amelioration of the compulsive behavior without adverse motor effects.

• Authors: Larry S Ivanco, Nicolaas I Bohnen
• Journal: American journal of therapeutics (Am J Ther) 2005 Sep-Oct Vol. 12 Issue 5 Pg. 467-8 ISSN: 1075-2765 [Print] United States
• PMID: 16148432 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cholinesterase Inhibitors
• Dopamine Agents
• Indans
• Piperidines
• Pergolide
• Levodopa
• Donepezil
• Amantadine
• Carbidopa

Topics

• Amantadine (adverse effects)
• Carbidopa (adverse effects)
• Cholinesterase Inhibitors (therapeutic use)
• Donepezil
• Dopamine Agents (adverse effects)
• Drug Therapy, Combination
• Humans
• Indans (therapeutic use)
• Levodopa (adverse effects)
• Male
• Middle Aged
• Parkinson Disease (drug therapy)
• Pergolide (adverse effects)
• Piperidines (therapeutic use)
• Sexual Dysfunctions, Psychological (chemically induced, drug therapy)