Pediatric
myocarditis is most often associated with the acute or subacute onset of
congestive heart failure in a previously healthy child.
Myocarditis presenting with acute, severe symptomatology, termed fulminant
myocarditis, has a high rate of recovery. Aggressive supportive care is indicated in fulminant
myocarditis, including mechanical circulatory support. For subacute
heart failure, supportive care remains the mainstay of
therapy for
myocarditis. A number of uncontrolled pediatric studies using both immunosuppressive therapy and/or immunomodulating
therapy with intravenous
gamma globulin have suggested these
therapies are safe and useful in treating pediatric
myocarditis. However, translating these results into recommended, routine
therapy for pediatric
myocarditis is complicated by the high rate of spontaneous improvement of
myocarditis with supportive care, and the lack of demonstrable benefit for immunosuppressive and immunomodulating
therapies in blinded, randomized, placebo-controlled trials in adult
myocarditis.
Heart transplantation remains the final therapeutic option for children with
myocarditis and intractable severe
heart failure.