Angiogenesis and cardioprotection after TNFalpha-inducer-Tolpa Peat Preparation treatment in rat's hearts after experimental myocardial infarction in vivo.

Abstract	The aim of the presented work was to evaluate whether short subcutaneous (s.c.) administration of TNFalpha-inducer-Tolpa Peat Preparation (TPP or TPP batch 0210) modulates the process of ischemic remodeling and spontaneous angiogenesis after experimental myocardial infarction (MI) in rats in vivo. The results obtained using three complementary and correlative methods: histological studies, Proliferating Cell Nuclear Antigen (PCNA) reaction and Lymphocytes Induced Angiogenesis (LIA) test showed a clear pro-angiogenic and cardioprotective effect of TPP administration after experimental MI. TPP batch 0210 should be considered as an angiogenesis stimulating factor and consecutively as a cardioprotective preventing development of ischemic cardiomyopathy after MI in rats. It might possibly be used as an adjunct to conventional therapy of coronary artery disease, including late phase after myocardial infarction or ischemic cardiomyopathy.
Authors	Tadeusz F Krzemiński, Jerzy K Nozyński, Joanna Grzyb, Maurycy Porc, Sławomir Zegleń, Violetta Filas, Ewa Skopińska-Rózewska, Ewa Sommer, Małgorzata Filewska
Journal	Vascular pharmacology (Vascul Pharmacol) Vol. 43 Issue 3 Pg. 164-70 (Sep 2005) ISSN: 1537-1891 [Print] United States
PMID	16043419 (Publication Type: Journal Article)
Chemical References	Amino Acids Carbohydrates Cardiotonic Agents Drug Combinations Humic Substances Tolpa Tumor Necrosis Factor-alpha Uronic Acids
Topics	Amino Acids (administration & dosage, pharmacology, therapeutic use) Animals Carbohydrates (administration & dosage, pharmacology, therapeutic use) Cardiotonic Agents (administration & dosage, pharmacology, therapeutic use) Disease Models, Animal Drug Combinations Humic Substances Immunohistochemistry Injections, Subcutaneous Male Myocardial Infarction (drug therapy, metabolism, pathology) Myocardium (metabolism, pathology) Neovascularization, Physiologic (drug effects) Rats Rats, Sprague-Dawley Tumor Necrosis Factor-alpha (biosynthesis) Uronic Acids (administration & dosage, pharmacology, therapeutic use) Ventricular Remodeling (drug effects)

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