HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Treatment of anthracycline extravasation in mice with dexrazoxane with or without DMSO and hydrocortisone.

Abstract
Dexrazoxane has been reported to be protective against anthracycline induced subcutaneous ulceration in mice. It is currently under clinical investigation as an acute antidote in accidental anthracycline extravasation, for which indication topical dimethylsulfoxide (DMSO) and intralesional hydrocortisone are used empirically. We studied the effect in 72 mice of monotherapy with and combined therapy of intraperitoneal dexrazoxane, topical DMSO, and intralesional hydrocortisone as acute antidotes against ulceration after subcutaneous daunorubicin. Dexrazoxane completely prevented wounds from occurring, while neither DMSO nor hydrocortisone had any preventive effect. The addition of topical DMSO actually reduced the efficacy of dexrazoxane. In conclusion, the present study does not support the concomitant use of topical DMSO + systemic dexrazoxane or intralesional hydrocortisone + systemic dexrazoxane. Monotherapy with systemic dexrazoxane seems preferable and is highly efficacious in preventing ulceration.
AuthorsSeppo W Langer, Annemette V Thougaard, Maxwell Sehested, Peter Buhl Jensen
JournalCancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 57 Issue 1 Pg. 125-8 (Jan 2006) ISSN: 0344-5704 [Print] Germany
PMID16001176 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Antibiotics, Antineoplastic
  • Razoxane
  • Hydrocortisone
  • Dimethyl Sulfoxide
  • Daunorubicin
Topics
  • Administration, Topical
  • Animals
  • Antibiotics, Antineoplastic (adverse effects)
  • Daunorubicin (adverse effects)
  • Dimethyl Sulfoxide (administration & dosage, therapeutic use)
  • Drug Therapy, Combination
  • Extravasation of Diagnostic and Therapeutic Materials (drug therapy, etiology)
  • Female
  • Hydrocortisone (administration & dosage, therapeutic use)
  • Injections, Intralesional
  • Injections, Intraperitoneal
  • Mice
  • Mice, Inbred Strains
  • Razoxane (administration & dosage, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: