5-HT 1A polymorphism and self-transcendence in mood disorders.

Abstract

Recently, an association between serotonin 1A receptor binding potential and self-transcendence scores at the temperament and character inventory (TCI) has been reported. We tested involvement of 5-HT(1A) gene in this trait, in a sample of 40 remitted mood disorder patients. Subjects with the 5-HT(1A)*C/C genotype showed significantly lower scores at the total self-transcendence and at the sub-scales of transpersonal identification and spiritual acceptance. Our preliminary results further support the involvement of the serotoninergic pattern in the self-transcendence character trait.

• Authors: Cristina Lorenzi, Alessandro Serretti, Laura Mandelli, Viviana Tubazio, Cristina Ploia, Enrico Smeraldi
• Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (Am J Med Genet B Neuropsychiatr Genet) Vol. 137B Issue 1 Pg. 33-5 (Aug 05 2005) ISSN: 1552-4841 [Print] United States
• PMID: 15952185 (Publication Type: Journal Article)
• Copyright: (c) 2005 Wiley-Liss, Inc.

Chemical References

• Receptor, Serotonin, 5-HT1A

Topics

• Adult
• Alleles
• Female
• Gene Frequency
• Genotype
• Humans
• Male
• Middle Aged
• Mood Disorders (genetics, psychology)
• Polymorphism, Genetic
• Psychiatric Status Rating Scales
• Receptor, Serotonin, 5-HT1A (genetics)
• Self Concept